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KMID : 0352419920110010121
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Keimyung Medical Journal
1992 Volume.11 No. 1 p.121 ~ p.130
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Immunohistochemical analysis of Estrogen Receptor in Endometrial Adenocarcinoma Using ER-D5 Antibody
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Abstract
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An immunohistochemical localization of estrogen receptor using specific estrogen receptor, ER-D5 monoclonal antibody raised against affinity-purified cytosol estradiol receptor which has a cytoplasmic location of the estradiol binding unit was
performed
on paraffin embedded tissue after formalin derived from 40 cases of endometrial adenocarcinoma examined at Keimyung University Dongsan Medical Center from January, 1984 to June, 1990.
@ES The results are as follows:
@EN 60% of endometrial adenocarcinoma are ER positive
According to grade of differention ER positivities are grade 1 : 87.5%, grade 2 : 78.5%, grade 3: 40%
Papillary and serous adenocarcinomas are all ER negative
The rate of ER positivity is slightly higher in premenopausal than postmenopausal
We should pay attention to the fact that the high grade cancer is not always ER positive while low grade cancer is not alway ER negative, and ER negative primary cancer confers high probalblity of treatment failure.
This study reported should serve to alert others to probable need to ER detection in advance in order to have a rational selection of patients for treatment with a specific therapy.
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KEYWORD
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